University of Texas at Austin


Publications
37. Zheng M., Zhang X., Zhou Y., Tang J., Han Q., Zhang Y., Ni Q., Chen G., Jia Q., Yu H., Liu S., Robins E., Jiang N., Wan Y., Li Q.J., Chen Z.N., Zhu P., "TCR repertoire and CDR3 motif analyses depict the role of αβ T cells in Ankylosing spondylitis", EBioMedicine, 2019 Sep;47:414-426
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36. Del Alcazar D., Wang Y., He C., Wendel B.S., Del Rio-Estrada P.M., Lin J., Ablanedo-Terrazas Y., Malone M.J., Hernandez S.M., Frank I., Naji A., Reyes-Teran G., Jiang N., Su L.F., "Mapping the Lineage Relationship between CXCR5+ and CXCR5− CD4+ T Cells in HIV-Infected Human Lymph Nodes", Cell Rep., 2019 Sep 17;28(12):3047-3060.e7.

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35. Moreno A.M., Palmer N., Aleman F., Chen G., Pla A., Jiang N., Chew W.L., Law M., Mali P., "Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy", Nat. Biomed. Eng.,2019, Oct;3(10):806-816
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34. Ma K.Y., Schonnesen A.A., Brock A., Van Den Berg C., Eckhardt S.G., Liu Z., Jiang N., "Single Cell RNA Sequencing of Lung Adenocarcinoma Reveals Heterogeneity of Immune Response-related Genes", JCI Insight,2019;4(4):e121387.
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33. Jiang N., Schonnesen A., Ma K.Y., "Ushering in Integrated T Cell Repertoire Profiling in Cancer", Trends in Cancer,Feb;5(2):85-94.
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32. Singarapu N., Ma K.Y., Reeh K., Shen J., Lancaster J., Yi S., Xie H., Orkin S., Manley N., Ehrlich L., Jiang N., Richie E., "Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment", Scientific Report,2018 Sep 25;8(1):14335.
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31. Zhang S.Q., Ma K.Y., Schonnesen A., Zhang M., He C., Sun E., Williams C., Jia W.*, Jiang N.*, "High-throughput determination of the antigen specificities of T cell receptors in single cells", Nature Biotechnology,2018 Nov 12.
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30. Ben S. Wendel, Daniel Del Alcazar, Chenfeng He, Perla M. Del Rio-Estrada, Benjamas Aiamkitsumrit, Yuria Ablanedo-Terrazas, Stefany M. Hernandez, Ke-Yue Ma, Michael Betts, Laura Pulido, Jun Huang, Phyllis A. Gimotty, Gustavo Reyes-Teran, Jiang N.*, Laura F. Su*, "The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes." Science Immunology, 06 Apr 2018, Vol. 3, Issue 22, eaan8884,* co-correspondence
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29. Ma K.Y., He C., Wendel B.S., Williams C.M., Xiao J., Yang H., Jiang N., "Immune Repertoire Sequencing using Molecular Identifiers Enables Accurate Clonality Discovery and Clone Size Quantification." Frontiers in Immunology, doi: 10.3389/fimmu.2018.00033
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28. Rubelt F., Busse C.E., Bukhari S.A.C., Burckert J.P., Mariotti-Ferrandiz E., Cowell L.G., Watson C.T., Marthandan N., Faison W.J., Hershberg U., Laserson U., Corrie B.D., Davis M.M., Peters B., Lefranc M.P., Scott J.K., Breden F., The AIRR Community, Luning Prak E.T., Kleinstein, S.H., "Adaptive Immune Receptor Repertoire Community recommendations for sharing immune-repertoire sequencing data", Nature Immunology, 2017
27. He C., Wendel B.S., Xiao J., Chen K., Jiang N., "COLT-Viz: Interactive Visualization of Antibody Lineage Trees", BioRxiv, 2017. doi: https://doi.org/10.1101/219592
26. Wendel B.S., He C., Crompton P.D., Pierce S.K.,Jiang N., "A streamlined approach to antibody novel germline allele prediction and validation". Frontiers in Immunology, 2017 Sep 04; Doi.org/10.3389/fimmu.2017.01072. PMID: 28928742 PMCID: PMC5591497
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25. Wendel B. S., He C., Qu M., Wu D., Hernandez S.M., Ma K.Y., Liu E., Xiao J., Crompton P.D., Pierce S.K., Ren P., Chen K.,Jiang N., "Accurate Immune Repertoire Sequencing Reveals Malaria Infection Driven Antibody Lineage Diversification in Young Children". Nat. Commun., 2017 Sep 14;8(1):531. doi: 10.1038/s41467-017-00645-x. PMID: 28912592
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24. Williams C., Schonnesen A., Zhang S.Q., Ma K.Y., He C., Yamamoto T., Eckhardt S.G., Klebanoff C.A.,Jiang N., "Normalized synergy predicts that CD8 co-receptor contribution to TCR and pMHC binding decreases as TCR affinity increases in human viral-specific T cells". Frontiers in Immunology, 2017 Jul 28;8:894. PMID: 28804489 PMCID: PMC5532383
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23. Liu C., Obliosca J.M., Liu Y.- L., Chen Y.- A.,Jiang N., Hsin-Chih Yeh, "3D single-molecule tracking enables direct hybridization kinetics measurement in solution". Nanoscale, 2017, 9, 5664.
22. Jiang N., "Immune engineering: from systems immunology to engineering immunity". Proceedings of Current Opinion in Biomedical Engineeringe, 2017, 1, 54-62.
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21. Jiang N., Chen W., Jothikumar P., Patel J.M., Shashidharamurthy R., Selvaraj P., Zhu C., "Effects of anchor structure and glycosylation of Fcγ receptor III on ligand binding affinity". Proceedings of Mol. Biol. Cell, 2016, Nov 7; 27(22); 3449-3458.
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20. Chen K., Gogu V., Wu D., Jiang N., "COLT: Constrained Lineage Tree Generation from Sequence Data". Proceedings of IEEE International Conference on Bioinformatics and Biomedicine, 2016.
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19. Hart G.T., Akkaya M., Chida A.S., Wei C., Jenks S.A., Tipton C., He C., Wendel B.S., Skinner J., Keyentao K., Ongoiba A., Doumbo O., Traore B., Narum D.L., Jiang N., Crompton P.D., Sanz I., Pierce S.K., "The regulation of inherently autoreactive VH4-34-expressing B cells in individuals living in a malaria endemic area of West Africa", J. Immunol., 2016 Nov 15;197(10):3841-3849. PMID: 27798155 PMCID: PMC5113821
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18. Zhang S., Parker P., Ma K., He C., Shi Q., Cui Z., Williams C., Wendel B.S., Meriwether A., Salazar M.A., Jiang N., "Direct measurement of T cell receptor affinity and sequence from naive antiviral T cells", Sci. Transl. Med., 01 Jun 2016: Vol. 8, Issue 341, pp. 341ra77.
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17. Liu C., Liu Y.-L., Perillo E. P., Jiang N., Dunn A. K., Yeh H.-C., "Improving z-tracking accuracy in the two-photon single-particle tracking microscope", Appl. Phys. Lett, 107, 153701 (2015); doi: 10.1063/1.4932224
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16. Jia Q., Zhou J., Chen G., Shi Y., Yu H., Guan P., Lin R., Jiang N., Yu P., Li Q.J., Wan Y., "Diversity Index of Mucosal Resident T Lymphocyte Repertoire Predicts Clinical Prognosis in Gastric Cancer", OncoImmunology, 2015 Jan 22;4(4):e1001230. eCollection 2015. PMID: 26137399 PMCID: PMC4485732
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15. Wong Y., Jiang N., Ebert P., Kidd B.A., Muller S., Lund P.J., Juang J., Adachi K., Tse T., Birnbaum M.E., Newell E.W., Wilson, D.M., Grotenbreg G.M., Valitutti S., Quake S.R., Davis M.M., "Clonal Deletion Prunes, but does not Eliminate Self-Specific αβ CD8+ T Lymphocytes". Immunity, 2015 May 19;42(5):929-941. PMID: 25992863 PMC: 4455602
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14. Jiang N., Zhang S., Ma K., "A ID Card for T cells". Nat Biotechnol., 2014 Jul;32(7):639-40. PMID: 25004230
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13. Li J., Wu D., Jiang N., Zhuang Y., "Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion". J. Immunol., 2013 Nov 15;191(10):5052-64. PMID: 24123680 PMC3837387.
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12. Zhang Y., Jiang N., Klopocki A.G., McEver R.P., Zhu C., "P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces". PLOS ONE, 2013;8(2):e57202. Epub 2013 Feb 25. PMID:  23451187  PMCID:  PMC3581448.
11.

Jiang N., He J., Weinstein J.A., Penland L., Sasaki S., He X.S., Dekker C.L., Zheng N.Y., Huang M., Sullivan M., Wilson P.C., Greenberg H.B., Davis M.M., Fisher D.S., Quake S.R., "Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination". Science Translational Medicine, 2013, 5, 171ra19.

Discussed by Dr. Francis Collins in his NIH Director's blog, http://directorsblog.nih.gov/taking-a-snapshot-of-the-human-immune-system/#more-538

Reported by a Brazilian newspaper - Correio Braziliense

News report by The Doctor Will See You Now

http://www.thedoctorwillseeyounow.com/content/public_health/art3961.html

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10. Zhu C., Jiang N., Huang J., Zarnitsyna V.I., Evavold B.D., "Insights from in situ analysis of TCR-pMHC recognition: Response of an interaction network". Immunological Review, 2013 Jan;251(1):49-64.
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9. Jiang N., Weinstein J.A., Penland L., White R.A. III, Fisher D.S., Quake S.R., "Determinism and stochasticity during maturation of the zebrafish antibody repertoire". Proc Natl Acad Sci U S A., 2011 Mar 29;108(13):5348-53.
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8. Jiang N., Huang J., Edwards L.J., Zhang Y., Liu B., Beal C.D., Evavold B.D., Zhu C., "Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination". Immunity, 2011 Jan 28;34(1):13-23.
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Faculty of 1000, scored 10 "Exceptional", http://f1000.com/8208956 See Preview by P. Anton van der Merwe1 and Shaun-Paul Cordoba, "Late Arrival: Recruiting Coreceptors to the T Cell Receptor Complex", Immunity, 2011 Jan 28:34(1):1-3
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7. Huang J., Zarnitsyna V.I., Liu B., Edwards L.J., Jiang N., Evavold BD, Zhu C., "The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness", Nature, 2010; 464(7290):932-6.
6. Kim J.V., Jiang N., Tadokoro C.E., Liu L., Ransohoff R.M., Lafaille J.J., Dustin M.L., "Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites", J. Immunol. Methods 2010; 352(1-2):89-100.
5. Weinstein J.A. *, Jiang N. *, White R.A. III, Fisher D.S., Quake S.R., "High-throughput Sequencing of the Zebrafish Antibody Repertoire", Science, 2009; 324(5928):807-10.
* These authors contributed equally.
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4. Wasserman, H.A., Beal C.D., Zhang, Y., Jiang, N., Zhu, C., Evavold, B.D. "MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1", J. Immunol., 2008;181(10):6843-6849.
3. Chien, Y., Jiang, N., Li, F., Zhang, F., Zhu, C., Leckband, D. "Two Stage Cadherin Kinetics Require Multiple Extracellular Domains but Not the Cytoplasmic Region", J. Biol. Chem., 2008; 283: 1848-1856.
2. Li, P.*, Jiang, N.*, Nagarajan, S., Wohlhueter, R., Selvaraj, P., Zhu, C. "Affinity and Kinetic Analysis of Fc? Receptor IIIa (CD16a) Binding to IgG Ligands", J. Biol. Chem., 2007; 282: 6210-6221.
* These authors contributed equally.
1. Long, M., Chen, J., Jiang, N., Selvaraj, P., McEver, R.P., Zhu, C. "Probabilistic Modeling of Rosette Formation", Biophys. J., 2006; 91: 352-363.