Characterizing macrophage repolarization by engulfed apoptotic cells in regenerative medicine

• Summary: Macrophages that have engulfed apoptotic cells tend to polarize toward an anti-inflammatory (M2) phenotype over a pro-inflammatory (M1) phenotype. Our lab is interested in which characteristics of apoptotic cells cause this shift. We also utilize the anti-inflammatory nature of apoptotic cells to produce nanoparticle systems to aid in the calming of inflammation for regenerative medicine.